Posterior cerebral hypoperfusion in migraine without aura marie … anoxia meaning in hindi

Posterior cerebral hypoperfusion in migraine without aura marie

Posterior cerebral hypoperfusion in migra ine without aura marie denuelle, MD neurology service, rangueil hospital toulouse, france most of the cerebral blood flow (CBF) studies in migra ine have introduced the concept of a pattern different in migra ine with aura (MA) and migra ine without aura (moa). MA is characterized by a focal reduction of regional CBF in the posterior part of one hemisphere that usually, but not always, corresponds to the topography and tim ing of the reported symptoms. 1-5 the hypothesis of cortical spread ing depression (CSO) dur ing MA was suggested by milner in 1958. 6 recently, blood oxygen level-dependent (BOLD) functional magnetic resonance imag ing (fmri) has shown cerebrovascular changes in the cortex of migra ineurs while experienc ing a visual aura that closely resemble CSD. 7 in this study, a clear temporal and spatial correlation was established between the visual symptoms of the aura and the BOLD signal changes.Anoxia meaning in hindi in moa, no blood flow changes were noticed in several studies. 8-10 however, woods and colleagues have reported a bilateral decrease in regional CBF (rcbf) spread ing forward from visual associative cortex to parietal and occipitotemporal areas in a patient from the start of a spontaneous attack of moa. 11 S ince the initial positron emission tomography (PET) study performed by weiiler and colleagues, 12 further studies have shown activation in bra instem structures dur ing MA and moa. 13-16 then bra instem nuclei may participate in migra ine pathogenesis, probably in a dysfunctional mode of the anti-nociceptive network and cerebrovascular control. In a previous publication us ing PET, 17 we have reported hypothalamic and bra instem activation in spontaneous migra ine attacks recorded as soon as possible after onset.Anoxia meaning in hindi the aim of the present study, us ing the same design and the same patients, was to focus on cerebral relative hypoperfusion. 18 we used H 2 15 0 PET to study seven patients (six female, one male, mean age 38.1 years) dur ing a spontaneous migra ine attack. None of the patients was receiv ing prophylactic treatment. Mean time from attack onset to PET scan was 3 h 8 m in (range 2 h 15 m in to 3 h 50 m in). The postpa in relief PET scan was done with in 6 h of headache onset for all patients (from 4 hours 20 m inutes to 6 hours, mean time 5 hours 9 m inutes). Dur ing moa attacks, a relative hypoperfusion was found bilaterally in the occipital cortex and the posterior temporal and parietal cortex compared with the headache-free interval.Anoxia meaning in hindi the adjusted rcbf decrease was 10.34%. This relative hypoperfusion was significant when the patients are considered as a group as well as individuals ( in five out of seven patients). After pa in relief by sumatriptan, 4-6 h after onset, the relative hypoperfusion persisted. The adjusted rcbf decrease was 12.32% after sumatriptan. 18 national headache foundation’s 7 th headache research summit october 16, 2009 marie denuelle, MD – posterior cerebral hypoperfusion in migra ine without aura