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"This study demonstrated that a larger population of women with lesser degrees of hyperglycemia (i.E., IADPSG-defined gestational diabetes) were at risk for progression to prediabetes and type 2 diabetes," the study authors wrote. "Gestational diabetes according to the carpenter-coustan criteria as defined in this study was linked to higher outcome risks. Separation anxiety disorder icd 10 however, the risks for the large group of women meeting the IADPSG-defined criteria for gestational diabetes were substantial and cannot be ignored from a public health perspective."

The carpenter-coustan criteria involve a 50-g glucose challenge test, followed by a 3-hour 100-g oral glucose tolerance test. A diagnosis of gestational diabetes requires two abnormal glucose values during these tests, defined as a fasting plasma glucose level greater than 95 mg/dl, a 1-hour plasma glucose level greater than 180 mg/dl, a 2-hour plasma glucose level greater than 155mg/dl, or a 3-hour plasma glucose level greater than 140mg/dl.


The IADPSG criteria require only one abnormal value during a 2-hour 75-g oral glucose tolerance test. Definicion de anorexia wikipedia the abnormal values are defined as a fasting plasma glucose level of 92 mg/dl or greater (≥5.1 mmol/L), a 1-hour plasma glucose level of 180 mg/dl or greater (≥10.0 mmol/L), or a 2-hour plasma glucose level of 153 mg/dl or greater (≥8.5 mmol/L), the study authors said.

Asked for her perspective, caroline messer, MD, of lenox hill hospital in new york city and a spokesperson for the american association of clinical endocrinologists, said that using the new IADPSG criteria might make sense. "It certainly seems as though the old criteria using the 50-g and 100-g glucose tests is less effective and perhaps we should only be using the 75-g test," said messer, who was not involved in the study.

Metzger and colleagues also examined whether the children of mothers with IADPSG-defined gestational diabetes were at greater risk for obesity or overweight as defined by body-mass index, compared with children of mothers without gestational diabetes. However, the team found only a nonsignificant trend toward higher risk for obesity or overweight (OR 1.21; 95% CI 1.00-1.46; RD 3.7%; 95% CI -0.16% to 7.5%). Anxiety meaning the results were similar when overweight and obesity were examined, as measured by percentage of body fat and waist circumference.

The IADPSG criteria were based in part on data from the hyperglycemia and adverse pregnancy outcome ( HAPO) study, a large, multinational, racially and ethnically diverse cohort study whose results were first reported in 2008. Metzger’s group performed a follow-up analysis, which included 4,697 mothers and 4,832 children from the original study. All participants underwent a single study visit between february 2013 and december 2016. At this visit, the investigators took clinical measurements, including height and weight, and performed a 2-hour 75-g oral glucose tolerance test following an 8-hour overnight fast on the mothers.

The primary outcome for the mothers was development of type 2 diabetes or pre-diabetes. History of hypoxic ischemic encephalopathy icd 10 type 2 diabetes was determined by self-reported treated diabetes or a fasting plasma glucose level of 126 mg/dl or greater (≥7.0 mmol/L), a 2-hour plasma glucose level of 200 mg/dl or greater (≥11.1 mmol/L), or both, during the oral glucose tolerance test at the study visit. Pre-diabetes was defined as a fasting plasma glucose level between 100 and 125 mg/dl (5.6-6.9 mmol/L), a 2-hour plasma glucose level between 140 and 199 mg/dl (7.8-11.0 mmol/L), or both. The primary independent variable for the mothers was gestational diabetes while enrolled in the HAPO study, defined post-hoc by the IADPSG criteria.

An important limitation to the analysis, the researchers said, was that nearly 2% of participants with oral glucose tolerance test values higher than predefined thresholds during pregnancy were unblinded and excluded from the primary analyses as well as from the follow-up assessment. "This subgroup likely would have included mothers with higher outcome frequencies for type 2 diabetes and prediabetes at the time of this follow-up study and children at the highest risk of overweight or obesity; therefore, the reported associations may be underestimates," metzger and co-authors wrote.