Miodocalm – instructions for use, indications, doses reflex anoxic seizures

Midokalm is a central muscle relaxant. Form of issue and composition

Dosage form: coated tablets: round, convex on both sides, white or almost white, engraved on one side (50 or 150), with a weak characteristic odor (10 pcs in blisters, 3 each blister in a pack of cardboard).

Composition of the preparation:

• active substance: tolperisone hydrochloride – 50 or 150 mg in 1 tablet;

• auxiliary components: stearic acid, corn starch, microcrystalline cellulose, colloidal silicon dioxide, citric acid monohydrate, talc, lactose monohydrate.

Sheath composition: titanium dioxide (E171), hypromellose, lactose monohydrate, colloidal silicon dioxide, macrogol 6000.


Indications for use

• pathologically increased tone and spasms of the striated muscles, arising from organic diseases of the central nervous system: myelopathy, cerebral stroke, affection of pyramidal pathways, encephalomyelitis, multiple sclerosis;

reflex anoxic seizures

• increased tone and muscle spasms, muscle contractures accompanying diseases of the movement organs, including arthrosis of large joints, spondylosis, cervical and lumbar syndromes, spondylarthrosis;

• little’s disease (cerebral spastic paralysis) and other encephalopathies, which are accompanied by muscular dystonia;

• diseases resulting from violations of vascular innervation: intermittent angioedema dysbasia, acrocyanosis (as part of combination therapy);

• obliterating vascular diseases: raynaud’s disease, diabetic angiopathy, diffuse scleroderma, obliterating arteriosclerosis, obliterating thromboangiitis (in combination therapy).

Also, midokalm is used for restorative treatment in the period after traumatology and orthopedic operations.Reflex anoxic seizures contraindications

• children under 3 years;

• pregnancy;

• lactation;

• myasthenia gravis;

• hypersensitivity to the drug.

Dosing and administration

Midokalm should be taken orally, swallowing tablets whole, washed down with water, after eating.

Recommended doses:

• adults and children over 14 years: 50 mg 2-3 times a day with a gradual increase to 150 mg 2-3 times a day;

• children 7-14 years: 2-4 mg / kg for 3 hours;

• children 3-6 years: 5 mg / kg for 3 hours.

Side effects

Possible side effects of miodocalm:

• central and peripheral nervous system: headache, muscle weakness;

• cardiovascular system: arterial hypotension;

• digestive system: a feeling of discomfort in the abdomen, nausea and vomiting;

• allergic reactions: rarely – hives, itching, erythema, anaphylactic shock, angioedema, bronchospasm.Reflex anoxic seizures

The described reactions usually pass after a decrease in the dose of the drug. Special instructions

To avoid complications, it is necessary to take medocalsm strictly in accordance with the recommendations of the attending physician.

Studies on the effect of the drug on the reaction rate and the ability to concentrate attention were not conducted. However, according to the data of long-term practice of application of midokalma, negative influence was not noted. Drug interactions

Tolperisone enhances the action of niflumic acid, which may require a reduction in its dose.

Clonidine, peripheral muscle relaxants, general anesthetics and psychotropic drugs enhance the effect of tolperisone.

Although mydocalm has an effect on the central nervous system, it does not cause sedation, so if necessary, it can be combined with hypnotics, sedatives and products containing ethanol.Reflex anoxic seizures terms and conditions of storage

Store at a temperature of 15-30 ° C in a place inaccessible to children, protected from moisture.

Shelf life is 3 years.