Hyperbaric oxygen treatment in autism spectrum disorders springermedizin.de significado de anoxia

DAR, CS, SHF, NO, SC, JAB and EAM treat individuals with hyperbaric treatment in their clinical practices and derive revenue from this. KVD works at a hyperbaric center and recommends HBOT, but does not derive revenue from hyperbaric treatments. JJB prescribes hyperbaric treatment but does not derive revenue from this. DAR and EAM have previously received research funding from the international hyperbarics association (IHA) for two studies of hyperbaric treatment in children with autism [ 85, 125] and CS previously received research funding from the IHA for one of these studies [ 125]. JAB has previously received research funding from the IHA for one study of hyperbaric treatment in children with autism and their parents.Significado de anoxia


EAM has received hyperbaric chambers and financial support from oxyhealth LLC for remodeling the rimland center, a center for mentoring clinicians interested in learning how to care for children with autism spectrum disorders. DAR and KVD are medical advisors (unpaid) for IHA. REF declares that he has no competing interests.

Traditionally, hyperbaric oxygen treatment (HBOT) is indicated in several clinical disorders include decompression sickness, healing of problem wounds and arterial gas embolism. However, some investigators have used HBOT to treat individuals with autism spectrum disorders (ASD). A number of individuals with ASD possess certain physiological abnormalities that HBOT might ameliorate, including cerebral hypoperfusion, inflammation, mitochondrial dysfunction and oxidative stress.Significado de anoxia studies of children with ASD have found positive changes in physiology and/or behavior from HBOT. For example, several studies have reported that HBOT improved cerebral perfusion, decreased markers of inflammation and did not worsen oxidative stress markers in children with ASD. Most studies of HBOT in children with ASD examined changes in behaviors and reported improvements in several behavioral domains although many of these studies were not controlled. Although the two trials employing a control group reported conflicting results, a recent systematic review noted several important distinctions between these trials. In the reviewed studies, HBOT had minimal adverse effects and was well tolerated.Significado de anoxia studies which used a higher frequency of HBOT sessions (e.G., 10 sessions per week as opposed to 5 sessions per week) generally reported more significant improvements. Many of the studies had limitations which may have contributed to inconsistent findings across studies, including the use of many different standardized and non-standardized instruments, making it difficult to directly compare the results of studies or to know if there are specific areas of behavior in which HBOT is most effective. The variability in results between studies could also have been due to certain subgroups of children with ASD responding differently to HBOT. Most of the reviewed studies relied on changes in behavioral measurements, which may lag behind physiological changes.Significado de anoxia additional studies enrolling children with ASD who have certain physiological abnormalities (such as inflammation, cerebral hypoperfusion, and mitochondrial dysfunction) and which measure changes in these physiological parameters would be helpful in further defining the effects of HBOT in ASD.