Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed anoxia anoxica

A study published this week in the journal carcinogenesis shows that in both cell lines and mouse models, grape seed extract (GSE) kills head and neck squamous cell carcinoma cells, while leaving healthy cells unharmed.

It’s a rather dramatic effect, says rajesh agarwal, phd, investigator at the university of colorado cancer center and professor at the skaggs school of pharmaceutical sciences.

It depends in large part, says agarwal, on a healthy cell’s ability to wait out damage.

Cancer cells are fast-growing cells, agarwal says. Not only that, but they are necessarily fast growing. When conditions exist in which they can’t grow, they die.

Grape seed extract creates these conditions that are unfavorable to growth.Anoxia anoxica specifically, the paper shows that grape seed extract both damages cancer cells’ DNA (via increased reactive oxygen species) and stops the pathways that allow repair (as seen by decreased levels of the DNA repair molecules brca1 and rad51 and DNA repair foci).

Yet we saw absolutely no toxicity to the mice, themselves, agarwal says.

Again, the grape seed extract killed the cancer cells but not the healthy cells.

I think the whole point is that cancer cells have a lot of defective pathways and they are very vulnerable if you target those pathways. The same is not true of healthy cells, agarwal says.

The agarwal lab hopes to move in the direction of clinical trials of grape seed extract, potentially as an addition to second-line therapies that target head and neck squamous cell carcinoma that has failed a first treatment.Anoxia anoxica

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I survived stage 4 basil and squamous cell carcinomas that progressed from my scalp to my spine (T3), two lung lobes and a large chest tumor. I had radiation and chemotherapy. And I adopted many of the discoveries I found on the internet. I avoided sugar and red meats. I also avoided lunch meat and processed meat, eggs, fat, salt and white bread. I consumed foods and supplements with anti-angiogenesis, apoptosis stimulating or COX2 inhibiting or anti-inflammatory or oxygen enhancing properties. I also consumed supplements that enhance chemotherapy or penetrate and repair cells or increase circulation or slow or block cancer from spreading.Anoxia anoxica I took resveratrol, flax seed oil, COQ10, quercetin, curcumin/cayenne, bromelian, garlic, gingo biloba, potatoes, fish, cranberry-grape juice, apple juice and orange juice., it is very important to know the grapes from which the GSE was extracted. Red grapes contain resveratrol, which may be effective in preventing prostate cancer growth. Wealthychef

Not rated yet jan 31, 2012

In response to 210 so can you take too much GSE? It would be VERY HARD, very. However, if I am allowed to assume total sanity in all users, GSE is slammed full of flavonoids; it is reaching for the gold medal in health foods that have not been modified or enhanced by human activity. Keep a packet of it with you and as you get that morning coffee, sprinkle it in.Anoxia anoxica if your daily work or gym workout sees you bringing along a water bottle or camelpack, I recommend a mixture of green tea, GSE, and or organic nettle tea: refill with bottled water at 1/4 consumed in your container and try to push at least 2.5 liters through your system. Workout as HARD as you can for the condition you are in, and for those of the’ persuasion’, go home, shower and then spend the next several hours giving your wife a vigorous massage in the lowest of light, the softest of music, the sweetest of incense, the phones switched off, but the movement should include nice long strokes, dig?? Word-to ya-muthas 210

Not rated yet feb 03, 2012