Evaluation of the effects of eserine and jwh-133 on brain dysfunction associated with experimental endotoxemia. brain anoxia

Summary of evaluation of the effects of eserine and JWH-133 on brain dysfunction associated with experimental endotoxemia.

Sepsis is associated with neuronal damage and cognitive impairment, with the participation of pro-inflammatory cytokines and oxidative-nitrous stress. It is known that activated microglia plays a vital role in neuro-inflammation and neuro-degeneration. Thus, the objective of this study was to evaluate therapeutic roles of two microglia regulating agents, JWH-133 and eserine, on the neuroinflammatory associated brain dysfunctions. To achieve our aim, we used control rats or submitted rats to lipopolysaccharide (LPS) challenge. 30min after LPS challenge, the animals received either saline, eserine, JWH-133 or eserine+JWH-133.Brain anoxia


after 24h, animals were submitted to the habituation to T maze, rotarod and activity cage tests. The rats were killed after and were evaluated for central and peripheral inflammatory and oxidative parameters. We observed that the use of eserine, JWH-133 or eserine+JWH-133 reverted the increases in the inflammatory markers [interleukin 6 (IL6), vascular cell adhesion molecule 1(VCAM-1) and eselectin] and oxidative-nitrous stress MDM, and that the anti-inflammatory, antioxidant properties of both JWH-133 and eserine successfully improve the LPS induced brain dysfunction. Affiliation

Journal details

This article was published in the following journal.

Name: journal of neuroimmunology ISSN: 1872-8421 pages: 9-16 links

brain anoxia

• pubmed source: http://www.Ncbi.Nlm.Nih.Gov/pubmed/25867462

• DOI: http://dx.Doi.Org/10.1016/j.Jneuroim.2015.02.008

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