Evaluation of the effects of eserine and jwh-133 on brain dysfunction associated with experimental endotoxemia. brain anoxia

Summary of evaluation of the effects of eserine and JWH-133 on brain dysfunction associated with experimental endotoxemia.

Sepsis is associated with neuronal damage and cognitive impairment, with the participation of pro-inflammatory cytokines and oxidative-nitrous stress. It is known that activated microglia plays a vital role in neuro-inflammation and neuro-degeneration. Thus, the objective of this study was to evaluate therapeutic roles of two microglia regulating agents, JWH-133 and eserine, on the neuroinflammatory associated brain dysfunctions. To achieve our aim, we used control rats or submitted rats to lipopolysaccharide (LPS) challenge. 30min after LPS challenge, the animals received either saline, eserine, JWH-133 or eserine+JWH-133.Brain anoxia

after 24h, animals were submitted to the habituation to T maze, rotarod and activity cage tests. The rats were killed after and were evaluated for central and peripheral inflammatory and oxidative parameters. We observed that the use of eserine, JWH-133 or eserine+JWH-133 reverted the increases in the inflammatory markers [interleukin 6 (IL6), vascular cell adhesion molecule 1(VCAM-1) and eselectin] and oxidative-nitrous stress MDM, and that the anti-inflammatory, antioxidant properties of both JWH-133 and eserine successfully improve the LPS induced brain dysfunction. Affiliation

Journal details

This article was published in the following journal.

Name: journal of neuroimmunology ISSN: 1872-8421 pages: 9-16 links

brain anoxia

• pubmed source: http://www.Ncbi.Nlm.Nih.Gov/pubmed/25867462

• DOI: http://dx.Doi.Org/10.1016/j.Jneuroim.2015.02.008

PubMed articles

[ 29689 associated pubmed articles listed on bioportfolio]

Interaction of IL-6 and TNF-α contributes to endothelial dysfunction in type 2 diabetic mouse hearts.

Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), are individually considered as important contributors to endothelial dysfunction in obesity and type 2 diabe…

High-dimensional therapeutic inference in the focally damaged human brain.

Though consistency across the population renders the extraordinarily complex functional anatomy of the human brain surveyable, the inverse inference-from common functional maps to individual behaviour…Brain anoxia

The effects of cardiotrophin-1 on early synaptic mitochondrial dysfunction and synaptic pathology in appswe/ps1de9 mice.

The coexistence of neuronal mitochondrial pathology and synaptic dysfunction is an early pathological feature of alzheimer’s disease (AD). Cardiotrophin-1 (CT-1) has been shown to exhibit impressive n…

Effects of fractionated whole-brain irradiation on cellular composition and cognitive function in the rat brain.

The aim of this study was investigate whether histopathological changes in the neurogenic region correlate with appropriate cognitive impairment in the experimental model of radiation-induced brain in…

Neuroprotective effects of C-terminal domain of tetanus toxin on rat brain against motorneuron damages after experimental spinal cord injury.Brain anoxia

Experimental animal study investigating the efficacy of C-terminal domain of tetanus toxin application as neuroprotective effects on rat brain in a model of spinal cord injury.

Clinical trials

[ 9769 associated clinical trials listed on bioportfolio]

Evaluate the effects of tolcapone on cognitive and behavioral dysfunction in patients with TBI and MCI

The experimental design is an open-label two-week trial of tolcapone to evaluate which

Clinical domains are affected by tolcapone treatment and to identify responders to

Tolcapone treatm…

Evaluation of carbohydrates

The study is open-label with a randomized, cross-over design using standard gl methodology.

Correcting platelet dysfunction after traumatic brain injury

brain anoxia

This study evaluates the impact of platelet transfusion on geriatric patients with platelet

Dysfunction from traumatic brain injury. The authors hypothesize that patients will recover


Targeted evaluation, action, monitoring of traumatic brain injury

TEAM-TBI (targeted evaluation, action, and monitoring of traumatic brain injury) is a

Research study that brings together TBI patients, advanced evaluation methods, and experts

In a multi-…

Evaluation of carbohydrates part 2

The study is single-blind with a randomized, cross-over design to evaluate gastrointestinal

Tolerance of carbohydrate blends.

Drug evaluation, preclinical

Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.Brain anoxia

Brain damage, chronic

A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.


A BRAIN-specific hyalectin that may play a role in terminally differentiating NEURONS. It is found highly overexpressed in primary BRAIN TUMORS and in experimental models of GLIOMA.

Brain diseases, metabolic

Acquired or inborn metabolic diseases that produce brain dysfunction or damage. These include primary (i.E., disorders intrinsic to the brain) and secondary (i.E., extracranial) metabolic conditions that adversely affect cerebral function.Brain anoxia

Hepatolenticular degeneration

A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting atpase 2 (EC, also known as the wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.