Endogenous stem cell-based brain remodeling in mammals – google หนังสือ anoxic brain injury causes

This text highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles and discusses possible ways it might be manipulated for medical purposes. The first section provides a descriptive summary of the salient steps of human brain development with a discussion of comparisons with other mammalian brains. It also provides a historical perspective on our understanding of ongoing brain development throughout the lifespan and serve to introduce the concept of brain plasticity following injury. The second part is devoted to the endogenous reparative potential of the brain, including its limitations, and articles focusing on defined pathologies (e.G.

Anoxia/hypoxia, epilepsy, traumatic brain injury and stress) in animal models and in humans pinpoint eventual ways these pathologies might be manipulated.Anoxic brain injury causes the third and final focuses on the dark side of stem cells for brain repair or of the manipulation of spontaneous adaptive events after injury (e.G. Genomic instability, sensitization to cancerous transformation and defective neural networks).

Acad sci U S A activity adult brain adult mice adult neurogenesis adult rat aneuploidy astrocytes axons biol brain res brdu cajal cancer cell cycle cerebral chromosome cortex cortical dendritic dendritic spines dentate gyrus dgcs differentiation EGFR embryonic stem cells endogenous epilepsy expression fibers functional gage FH gene genetic genomic glia glial glioma granule cells growth factor hippocampal hypothalamic increased ipscs junier lesions lineage markers mature mechanisms median eminence migration molecular mouse mutations myelin nat neurosci natl acad sci neonatal nestin neural cells neural progenitors neural stem cells neural stem/progenitor cells neurobiol neurogenic neurons neurosci newborn olig2 oligodendrocyte progenitors pathways plasticity pluripotent stem cells postnatal potential proc natl acad progenitor cells protein receptor regeneration regulation remodeling remyelination rodent role seizures signaling sotelo spinal cord striatum studies subventricular zone synaptic tanycytes tion tissue transgenic traumatic brain injury tumor ventricle vitro vivo

anoxic brain injury causes

Dr. Steven G. Kernie is an associate professor of pediatrics and pathology cell biology at columbia university in new york and chief of critical care medicine at morgan stanley children’s hospital at columbia university medical center. His laboratory is interested in how the brain repairs itself following injury. The presence of adult neural stem and progenitor cells in the mammalian brain has awakened new interest and optimism in potential treatment for a variety of acquired brain disorders. The kernie lab is investigating how adult neural stem and progenitor cells participate in injury-induced remodeling and in identifying genes and drugs that might be important in augmenting their contribution.Anoxic brain injury causes in order to do this, they have generated a variety of transgenic mice that allow for temporally controlled alterations in the endogenous stem cell population in order to optimize the post-injury remodeling that occurs.

Dr. Marie-pierre junier is research director at inserm and co-PI of team glial plasticity for the center of research neuroscience paris seine at the university pierre et marie curie. Her team showed the permissiveness of astrocytes to re-programming into immature states akin to neural progenitors or neural stem cells. It further demonstrated that these plastic capabilities of astrocytes sensitize them to cancerous transformation. The team is now using cancer stem cells isolated from human adult and pediatric gliomas to understand their differences from normal human neural stem cells.Anoxic brain injury causes combining proteomic, metabolic and epigenetic approaches, the team aims at developing new therapeutic strategies against these devastating cancers.