Conference detail for photons plus ultrasound imaging and sensing 2019 hypoxic ischemic encephalopathy in adults symptoms

Hemorrhagic shock, as an important clinical issue, is regarding as a scary disease with high mortality rate. Unfortunately, existing clinical technologies are inaccessible to assess the hemorrhagic shock via hemodynamics in microcirculation. Here we propose an ultracompact photoacoustic microscope to assess hemorrhagic shock using a rat model. We carried out in vivo experiments for different organs including brain, intestine, ovary, and bladder. Both functional and morphological features of the micro-vascular network including concentration of total hemoglobin (CHbT), number of blood vessels (VN), small vascular density (SVD) and vascular diameter (VD) were derived to assess the microvascular hemodynamics of different organs.


In addition, we successfully imaged the vasculatures of human lip and hypogloeeis with capillary-level resolution in three-dimension. prognosis after anoxic brain injury Animal studies show the feasibility of the proposed tool to assess and stage the hemorrhagic shock via microcirculation. In vivo oral imaging of healthy volunteers indicates the translational possibility of this technique for clinical evaluation of hemorrhagic shock.

We report our experimental study on enhancement of photoacoustic (PA) signal from contrast dye by pre-illumination of the dye with continuous wave (CW) light beam other than optical pulse (pulse width ~nsec) that is employed to irradiate tissue sample for inducing thermoelastic expansion and subsequently, generation of photoacoustic waves. This unique technique is in contrast to the conventional approaches of shift of optical absorption peak – in the characteristic absorption spectrum of (PA signal) contrast dyes, say, nano-particles – by control of the physical parameters including structure, shape and size. anxiety attack meaning in tamil Experiments were conducted – employing home-built photoacoustic (acoustic resolution) microscopy imaging system for measurement of PA signal strength induced – under various conditions: (1) without any pre-illumination of the dye with CW laser beam, i.e., only pulse laser beam is employed to irradiate the dye and (2) with pre-illumination of the organic dye at various time durations of pre-illumination. In this second case, the dye is exposed, firstly, to CW laser beam (of wavelength, 642nm) for a pre-specified time interval that is followed by irradiation of the dye with pulse laser (~6nsec) for inducing PA waves. The experimental results demonstrate that pre-illumination of the organic dye improves significantly the strength of pulse-laser induced photo-acoustic signal strength. It is a promising technique for end application in biomedical and clinical applications (more specifically, for enhancement of PA signal strength).

In this work, our recently developed photoacoustic physio-chemical analysis (PAPCA) method has been investigated for evaluating the presence and aggressiveness of prostate cancer. reflex anoxic seizures in infants A total of 101 fresh tissue specimens from prostatectomy have been involved in this ex vivo study. Each specimen was scanned over a broad optical spectrum of 690-950nm and 1200-1700 nm by using a broad bandwidth needle hydrophone. With the 2D spectrograms of all the specimens, machine learning is introduced to reveal the changes associated with the cancerous process of prostate tissue. We combined the Pearson correlation coefficient and UPGMA, an unsupervised hierarchical clustering method, to judge the characteristic optical wavelength range that is the most sensitive to the difference in molecular components, which lays a foundation for the detection of prostate cancer by PAPCA method. anxiety meaning in urdu With the accumulation of sample numbers, the dispersion of data may gradually increase. Thus, LDA and QDA, two classification methods in machine learning, were introduced to extracting more diversity character between normal and tumor tissues for classification. The combination of PAPCA and machine learning methods has shown satisfactory results in prostate cancer identification. More than 70% accuracy was achieved. The method described in this paper may be developed into a clinical tool for not only diagnosis but also assessing the aggressiveness of prostate cancer.

As the excellent conversion efficiency of light-thermal and light-acoustics of gold nanoparticles (GNPs) at the plasmonic resonant wavelength, the consequent combination of photoacoustic imaging (PAI) and photothermal therapy (PTT) via GNPs shows a promising prospect because of convenience and noninvasiveness. However, more problems need to be solved in facilitating the translation of basic science to the clinical setting, including chemical toxicity through GNPs preparation, distribution uniformity, stability of GNPs during repeating monitoring and treatment etc. In this study, we made gold nanostars without toxic surfactant combined with coated silicon on GNSs as mold to maintain the shape of star, which could keep their absorption features very well as demonstrated via material and animal experiments. We assembled the silicon-coated GNSs into the vesicles inside the stem cells to improve the distribution uniformity and passive targeting of GNSs to tumor benefiting from the homing effect of stem cells. hypoxic ischemic encephalopathy treatment in india The animal experiments proved that the system of stem cells loaded with silicon-coated GNSs not only enhances the uniformity of photo-thermal therapy but also the stability of repeated PAI and PTT. Silicon-coated GNSs could be developed into a composite theranostic agent which is excellent for repeated imaging and therapy of cancer.

High-intensity focused ultrasound (HIFU) ablation is a promising non-invasive surgical technology. nanoxia deep silence 6 rev b review A major challenge for HIFU ablation is how to locate, visualize, and monitor the treatment region process in real time, so that the success rate can be improved, and favorable prognosis can be guaranteed. Here, we develop an array-based HIFU treatment system integrated with ultrasound and photoacoustic imaging capability. The HIFU’s focus can be electronically steered in 3D space, and the system can acquire both ultrasound and photoacoustic images to monitor structural, functional, and temperature information of the ablation regions in real time. The 3D-array-based HIFU transducer can also be used to acquire ultrasound or photoacoustic images in 3D space, which augments the imaging view angle. Phantom experiments validate the fast steering capability of HIFU ablation. The ultrasound, photoacoustic imaging and temperature monitoring capability in the requested region are also demonstrated in biological tissue.