Bajanomad – baja nomad prayer power needed – powered by xmb anoxic anoxia

Posts: 8215

Registered: 2-9-2004

Location: I.E. ‘951’

Member is offline

Mood: got baja?

Posted on 8-29-2008 at 06:15 PM

Thank you, everyone. I’ve been too afraid to take the jeep out of its’ garage. So, there it sits..Awaiting another baja adventure.

I am staying at my parents house across town. They’re driving me to my house for the day and bringing me back to their house to sleep at night.

On wednesday, I will be going in for an echocardiogram to determine exactly what is not functioning properly. I have 23 sick days accumulated, so

Expect to see lots more posting from me – your new armchair baja traveler.

I was hospitalized yesterday – just spending 30 min. At work, and I got the rest of the day off, with a private coach to ER where I spent the day with

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My parents.

As far as baja goes, my mother actually pushed me across the san ysidro border in a stroller back in the late 60s. We all spent 21+ days lounging on

The beach in rosarito WITHOUT TOURIST VISAS, because back in the 70s, nobody cared. Hahaha

Thanks again for everyones kind wishes.

[edited on 8-30-2008 by ken cooke]

Posts: 1096

Registered: 9-13-2006

Location: rosarito california

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Mood: enjoying life with wife in mexico, easy on the easy

Posted on 8-30-2008 at 11:53 PM

Ken, hope you get well soon and sometimes we just get too stressed out and do not know it until our body demands we slow it down. I just had my knee

Operated on a week ago and I had to go through a number of tests you did as a similar thing happened to me about a year ago.Anoxic anoxia due to that the doctor

Insisted all of the tests your getting I had to do over again due to him saying he was taking no chances with me on the operating table for my knee

With this floating out there. Well, everything checked out excellent and operation went well and recoperating now. So, slow down no red meat eat the

Chicken, fish, pastas, leave the beer alone for awhile and soon my friend everything ticking well for you. Easy on the easy and remember we still

Need to link up at some nomad gathering in the near future. I have already sent a prayer for you and we all know through jesus all prayers are

Answer. Take care amigo———–later—-bajafun777

Ken cooke

Posts: 3401

Registered: 3-24-2007

Location: the valley of the moon

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Member is offline

Mood: peacefull

Posted on 9-1-2008 at 09:55 AM


Originally posted by fishbuck

Wow, ken! I don’t know much about maleria but hope it is treatable.

Get well soon so you can show me how to 4×4.

Try google for your answers ….


Section of brain showing blood vessels blocked with developing P. Falciparum parasites (see arrows) (RPH).

What is cerebral malaria?

Cerebral malaria (CM) collectively involves the clinical manifestations of plasmodium falciparum malaria that induce changes in mental status and

Coma. It is an acute, widespread disease of the brain which is accompanied by fever. The mortality ratio is between 25-50%. If a person is not

Treated, CM is fatal in 24-72 hours.Anoxic anoxia the histopathological hallmark of this encephalopathy is the sequestration of cerebral capillaries and venules

With parasitized red blood cells (prbcs) and non-prbcs (nprbcs). Ring-like lesions in the brain are major characteristics. Disease risk factors

Include being a child under 10 years of age and living in malaria-endemic area.

There is a clear need for a strict definition of cerebral malaria in order to properly diagnose and assess the condition. A pragmatic definition based

On the glasgow coma score exists. Its key elements are: (1) unrousable coma–no localizing response to pain persisting for more than six hours if the

Patient has experienced a generalized convulsion; (2) asexual forms of P.Anoxic anoxia falciparum found in blood; and (3) exclusion of other causes of

Encephalopathy, i.E. Viral or bacterial. (newton and warrell)

The blantyre coma scale, a related diagnostic tool, has been devised for young children.

What are the symptoms?

Clinical manifestations of cerebral malaria are numerous, but there are three primary symptoms generally common to both adults and children: (1)

Impaired consciousness with non-specific fever; (2) generalized convulsions and neurological sequelae; and (3) coma that persists for 24-72 hours,

Initially rousable and then unrousable.

What is the cause?

Sequestration of parasites and obstruction of brain vessels (RPH)

The cause of cerebral malaria is not well understood. Currently, there are two major hypotheses explaining its etiology.Anoxic anoxia they are the mechanical and

The humoral hypotheses.

The mechanical hypothesis asserts that a specific interaction between a P. Falciparum erythrocyte membrane protein (pfemp-1) and ligands on

Endothelial cells, such as ICAM-1 or E-selectin, reduces microvascular blood flow and induces hypoxia. This selective cytoadherence of prbcs and

Non-prbcs, also known as rosetting, can apparently better account for CM’s histopathological hallmark and its characteristic coma condition. However,

This hypothesis is inadequate in explaining the relative absence of neurological deficit even after days of unconsciousness.

The humoral hypothesis suggests that a malarial toxin may be released that stimulates macrophages to release TNF-a and other cytokines such as IL-1.Anoxic anoxia

The cytokines themselves are not harmful, but they may induce additional and uncontrolled production of nitric oxide. Nitric oxide would diffuse

Through the blood-brain barrier and impose similar changes on synaptic function as do general anesthetics and high concentrations of ethanol, leading

To a state of reduced consciousness. The biochemical nature of this interaction would explain the reversibility of coma.

What are possible treatment options?

As cerebral malaria is the fatal within days of malaria infection if left untreated, immediate treatment is crucial. Because natural immunity to

Malaria is not fully understood (immunity) and thus cannot yet be artificially imitated by drugs, control and prevention strategies are significant.Anoxic anoxia

Two of these are antimalarial chemotherapy and adjunctive measures. Public health interventions are also critical (public health).

P. Falciparum parasites in brain capillary (J.S. Tatz)

Chemotherapy for cerebral malaria now primarily involves the use of quinine, for a patient with severe CM must be assumed to have chloroquine

Resistance. It is one of the four main alkaloids found in the bark of the cinchona tree and is the only drug which over a long period of time has

Remained largely effective for treating the disease. Quinine has similar activity to chloroquine in that it is likely to interfere with the parasite’s

Enzymatic digestion.

Artemisinins have been shown in some clinical trials to clear parasitemia and fever faster than quinine or chloroquine, but they had no effect on

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Mortality rates. Artemisinin has been used by the chinese as a traditional treatment for fever and malaria. It is a sesquiterpene lactone derived from

Artemisia annua. The two most widely used are artesunate and artemether. Because it is both cheap and effective, it is beginning to be included in

Treatment schedules. However, it is not yet licensed for use in australia, north america or europe. Its main value is in the treatment of multi-drug

Resistant falciparum malaria. As the possibility of quinine resistance looms, artemisinin and its derivatives may soon become the drugs of choice for

CM treatment (newton and warrell).

Adjunctive measures for CM treatment exist, but they are debatable in both use and efficacy:

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Such as paracetamol to reduce fever. However, it is not clear if a reduction in core temperature benefits cerebral consequences.


Such as phenobarbital sodium for seizures. It is crucial to control or prevent seizures, as they can cause neuronal damage and are associated with a

Fatal outcome.

Reduce intracranial pressure

Using agents such as osmotic diuretics.

Hypoglycemia correction

Using hypertonic glucose. However, theoretically, correcting hypoclycemia in the presence of tissue hypoxia can worsen tissue acidosis.

Exchange transfusion

Generally only been justified when peripheral parasitemia exceeds 10% of circulating erythrocytes. The role of these blood transfusions remains

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Highly controversial, as they are both expensive and potentially dangerous in many malaria-endemic areas.


Such as corticosteroids. However, there have been few controlled studies demonstrating benefit.


An iron-chelating adjuvant agent with antimalarial properties. Reduces formation of reactive oxygen species by reducing amount of free iron.

Microcirculatory flow ­

Such as pentoxifylline. Reduces red cell deformability and blood viscosity, decreases systemic vascular resistance, and impairs platelet aggregation,

Thus improving microcirculatory flow.

In short, experimental data exists that demonstrates the efficacy of some ancillary therapies, but their roles are still controversial (newton and

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Pretty serious stuff.