Atorvastatin modulates regulatory t cells and attenuates cerebral damage in a model of transient middle cerebral artery occlusion in rats. anoxia perinatal

Summary of atorvastatin modulates regulatory T cells and attenuates cerebral damage in a model of transient middle cerebral artery occlusion in rats.

Regulatory T cells (tregs) inhibit the activation of the immune response which could down-regulate the systemic and focal activation observed during ischemic stroke. In fact, in animal models, tregs infiltrate the infarcted brain and reduce the pro-inflammatory cytokine production and infarct volume, mainly in late stages of ischemia. Recently, an expansion and greater suppressive capacity of circulating tregs after treatment with statins was observed, in addition to their cardio- and neuroprotective actions demonstrated previously.

Thus, to determine whether treg modulation mediated by statins can also be beneficial during stroke, cerebral ischemia was artificially induced in wistar rats by transient middle cerebral artery occlusion (tmcao) during 60 minutes with subsequent reperfusion for 7 days.Anoxia perinatal six hours after surgery, some animals were treated with atorvastatin (ATV, 10 mg/kg) or carboxymethylcellulose as vehicle at the same concentration every other day during 7 days. Some animals were sham operated as control group of surgery. Interestingly, ATV treatment prevented the development of infarct volume, reduced the neurological deficits, and the circulating and cervical lymph node CD25(+)foxp3(+) treg population. Moreover, there was a reduction of glial cell activation, which correlated with decreased circulating tregs. Remarkably, treatment with ATV induced an increase in the frequency of CD4(+)CD25(+) T cells, in particular of those expressing CTLA-4, in brain samples. Together, these results suggest that ATV can modulate tregs in peripheral tissue and favor their accumulation in the brain, where they can exert neuroprotective actions maybe by the reduction of glial cell activation.Anoxia perinatal affiliation

Journal details

This article was published in the following journal.

Name: journal of neuroimmune pharmacology : the official journal of the society on neuroimmune pharmacology ISSN: 1557-1904 pages: links

• pubmed source: http://www.Ncbi.Nlm.Nih.Gov/pubmed/27614888

• DOI: http://dx.Doi.Org/10.1007/s11481-016-9706-5

PubMed articles

[ 30187 associated pubmed articles listed on bioportfolio]

Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage.

The aim of the present study was to assess the therapeutic effects of atorvastatin on cerebral vessel autoregulation and to explore the underlying mechanisms in a rabbit model of subarachnoid hemorrha…Anoxia perinatal

Protein tyrosine phosphatase inhibition prevents experimental cerebral malaria by precluding CXCR3 expression on T cells.

Cerebral malaria induced by plasmodium berghei ANKA infection is dependent on the sequestration of cytotoxic T cells within the brain and augmentation of the inflammatory response. Herein, we demonstr…

The IL-2/anti-IL-2 complex attenuates cardiac ischaemia-reperfusion injury through expansion of regulatory T cells.

Regulatory T cells (tregs) can suppress immunologic damage in myocardial ischaemia/reperfusion injury (MIRI), however, the isolation and ex vivo expansion of these cells for clinical application remai…

Human papillomavirus E7 induces p63 expression to modulate DNA damage response.Anoxia perinatal

Cervical cancer is the third most common malignancy diagnosed in women worldwide. The major aetiological factor underlying the malignant transformation of cervical cells is the persistent infection wi…

Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke.

Delayed thrombolytic treatment with recombinant tissue plasminogen activator (tpa) may exacerbate blood-brain barrier breakdown after ischaemic stroke and lead to lethal haemorrhagic transformation. T…

Clinical trials

[ 10464 associated clinical trials listed on bioportfolio]

Anti-inflammatory effect of atorvastatin in atherosclerotic plaques assessed by FDG-PET imaging

The purpose of this study is to determine whether HMG-coa reductase inhibitor, atorvastatin

anoxia perinatal

Attenuates inflammation in atherosclerotic plaques detected by 18F-fluorodeoxyglucose(FDG)


Atorvastatin therapy in cerebral cavernous malformation: A proof of concept phase I/II trial

The study aims to demonstrate that extended course atorvastatin therapy reduces lesional

Iron deposition without increasing the risk of rebleeding (acute hemorrhage) in patients

With cereb…

Vasomotor reactivity in cerebral small vessel disease and new approach to treat lacunar stroke

The main purpose of this study is to evaluate the efficacy of atorvastatin treatment during

3 months (80mg/day) on cerebral vasoreactivity (CVR) in lacunar patients.

High dose atorvastatin for preventing periprocedural ischemic brain damage during carotid artery stenting

anoxia perinatal

The purpose is to test whether a short-term, high-dose atorvastatin treatment (80mg once a

Daily (QD) from 3 days before to 3 days after CAS, then 20 mg QD until 30 days after CAS) is


The threshold value of regional cerebral oxygenation in detecting cerebral ischemia

Using patients receiving spinal anesthesia as a model to evaluate the treshold value of

Cerebral oximeter to detect the symptoms of cerebral ischemia

T-lymphocytes, regulatory

CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting tr1 cells, and th3 cells.Anoxia perinatal

Models, statistical

Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.

G1 phase cell cycle checkpoints

Regulatory signaling systems that control the progression of the CELL CYCLE through the G1 PHASE and allow transition to S PHASE when the cells are ready to undergo DNA REPLICATION. DNA DAMAGE, or the deficiencies in specific cellular components or nutrients may cause the cells to halt before progressing through G1 phase.

Hypertensive encephalopathy

Brain dysfunction or damage resulting from sustained MALIGNANT HYPERTENSION.Anoxia perinatal when BLOOD PRESSURE exceeds the limits of cerebral autoregulation, cerebral blood flow is impaired (BRAIN ISCHEMIA). Clinical manifestations include HEADACHE; NAUSEA; VOMITING; SEIZURES; altered mental status (in some cases progressing to COMA); PAPILLEDEMA; and RETINAL HEMORRHAGE.

G2 phase cell cycle checkpoints

CELL CYCLE regulatory signaling systems that are triggered by DNA DAMAGE or lack of nutrients during G2 PHASE. When triggered they restrain cells transitioning from G2 phase to M PHASE.